Inter Miami face Atletico San Luis in their 2026 Leagues Cup debut, and many are wondering whether Lionel Messi will be available for this match. Inter Miami open their 2026 Leagues Cup campaign on Wednesday, August 5, hosting Atletico San Luis at Nu Stadium, with kickoff set for 7:30 p.m. ET. The Herons arrive unbeaten in their last seven MLS matches, while San Luis is still searching for its first win of the Apertura 2026 in Liga MX. For this crucial game, Lionel Messi will start. The Argentine returned from the World Cup off the bench in Inter Miami’s 2-2 draw against Columbus Crew last weekend, and coach Guillermo Hoyos will now hand him his first start since the tournament, alongside Rodrigo De Paul, who is also in the lineup after working his way back from international duty. Hoyos will have to make do without two key attacking pieces for the opener. Luis Suárez is unavailable for the entire tournament, serving the first match of a six-game Leagues Cup suspension stemming from his conduct in last year’s final against Seattle Sounders. Germán Berterame is also out, still recovering from the hard collision he suffered against CF Montreal that required an overnight hospital stay, leaving Mateo Silvetti as the likely option to partner Messi up front. Es hoy. Vamos Miami. 😤⚔️ #MIAvASL pic.twitter.com/7u1HpUfhIz— Inter Miami CF (@InterMiamiCF) August 5, 2026 Inter Miami confirmed lineup With Suárez, Berterame and also Tadeo Allende, who is recovering from knee surgery, ruled out for this match, Hoyos will feature a very different attack, but with Messi as starter. This is Miami’s confirmed starting XI: Ríos-Novo; Caicedo, Fray, Silva, Allen; Bright, Casemiro, De Paul, Segovia; Messi, Pinter. Atletico San Luis confirmed lineup Atletico San Luis arrive in a very different moment. The Mexican side has yet to find its footing in the Apertura, and this Leagues Cup opener gives them a chance to salvage some momentum against a strong Miami side. This is San Luis’ confirmed starting XI: Sánchez; Bambu, Álvarez, Águila; Torres, Salles-Lamonge, Macías, Esteves; Rodríguez, Flores, Llorente.