Lionel Messi is set to start as Inter Miami host Nashville SC in a crucial Eastern Conference clash. Lionel Messi will be in the starting lineup as Inter Miami host Nashville SC on Saturday at Nu Stadium, with interim head coach Guillermo Hoyos still in charge of the side while incoming coach Cristian “Kily” Gonzalez continues to await the work permit needed to officially take over. The stakes are significant for both sides. Miami sit third in the Eastern Conference on 44 points, nine behind a Nashville side that occupies first place despite having just suffered its first MLS defeat since late July, a 2-1 loss to Toronto FC. The Herons, for their part, have cooled off after their emphatic 7-1 rout of CF Montreal, following it up with back-to-back draws against Atlanta United and Chicago Fire that cost them valuable ground in the Supporters’ Shield race. Miami still boast the most potent attack in the league, having scored a league-high 59 goals this season, while Nashville counter with the competition’s stingiest defense, having conceded just 19. Tonight, together 👊#MIAvNSH • @MarriottBonvoy pic.twitter.com/5EHA37kJIU— Inter Miami CF (@InterMiamiCF) September 12, 2026 That contrast in styles, MLS’s most prolific offense against its most disciplined backline, sets up an intriguing tactical battle at Nu Stadium, with Messi’s ability to find space between the lines likely to be decisive. Inter Miami confirmed lineup Hoyos will have to make do without Mateo Silvetti, Santiago Morales and Tadeo Allende, all ruled out through injury, leaving the club with three absences to account for heading into kickoff. Inter Miami confirmed starting XI: Dayne St. Clair; Ian Fray, Casemiro, Maximiliano Falcon, Fricio Caicedo; Rodrigo De Paul, Yannick Bright, Telasco Segovia; Lionel Messi, German Berterame, Luis Suarez. Nashville SC probable lineup Nashville are set to line up in a 4-3-3 of their own, with Warren Madrigal unavailable because of a lower-body injury, opening the door for Cristian Espinoza to retain his place alongside Sam Surridge and Hany Mukhtar up top. Nashville SC probable starting XI: Brian Schwake; Andy Najar, Jeison Palacios, Maxwell Woledzi, Reed Baker-Whiting; Patrick Yazbek, Matthew Corcoran, Alex Muyl; Cristian Espinoza, Sam Surridge, Hany Mukhtar.