| # | Player | Team | Goals Total | Assists | Appearances | Minutes | Rating |
|---|---|---|---|---|---|---|---|
| 1 |  A. Dreyer |  San Diego | 8 | 10 | 21 | 1856 | 7.57 |
| 2 |  L. Messi |  Inter Miami | 18 | 9 | 19 | 1610 | 8.59 |
| 3 |  C. Espinoza |  Nashville SC | 3 | 9 | 18 | 1267 | 7.03 |
| 4 |  Evander |  FC Cincinnati | 12 | 8 | 21 | 1686 | 7.88 |
| 5 |  Son Heung-Min |  Los Angeles FC | 4 | 8 | 21 | 1671 | 7.22 |
| 6 |  J. Pereyra |  Minnesota United FC MIN | 3 | 8 | 22 | 1937 | 7.57 |
| 7 |  P. Zinckernagel |  Chicago Fire CHI | 5 | 7 | 20 | 1604 | 7.36 |
| 8 |  T. Segovia | Inter Miami | 3 | 7 | 20 | 1627 | 6.82 |
| 9 |  A. Rusnak |  Seattle Sounders SEA | 3 | 7 | 20 | 1492 | 6.86 |
| 10 |  J. Valiente |  FC Dallas DAL | 1 | 7 | 20 | 1309 | 6.76 |
| 11 |  P. Owusu |  CF Montreal MON | 13 | 6 | 21 | 1735 | 7.19 |
| 12 |  H. Mukhtar | Nashville SC | 10 | 6 | 22 | 1785 | 7.3 |
| 13 |  Pep Biel |  Charlotte | 10 | 6 | 22 | 1858 | 7.14 |
| 14 |  A. Ojeda |  New York City FC | 5 | 6 | 22 | 1818 | 7.01 |
| 15 |  A. Miranchuk |  Atlanta United FC | 5 | 6 | 21 | 1726 | 7.04 |
| 16 |  K. Velde |  Portland Timbers POR | 5 | 6 | 21 | 1791 | 7.08 |
| 17 |  R. De Paul | Inter Miami | 4 | 6 | 17 | 1440 | 7.55 |
| 18 |  M. Reus |  Los Angeles Galaxy ANG | 4 | 6 | 21 | 1534 | 6.88 |
| 19 |  D. Da Costa | Portland Timbers POR | 3 | 6 | 19 | 1619 | 7.04 |
| 20 |  L. Langoni |  New England Revolution ENG | 3 | 6 | 15 | 887 | 6.96 |